CALL FOR PAPERS Neural Integration of Peripheral Signals Implicated in the Control of Energy Homeostasis and Metabolism Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
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چکیده
James E. Blevins, Gregory J. Morton, Diana L. Williams, David W. Caldwell, Lloyd S. Bastian, Brent E. Wisse, Michael W. Schwartz, and Denis G. Baskin Veterans Affairs Puget Sound Health Care System, Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle; Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Seattle; and Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington
منابع مشابه
Leptin action in the forebrain regulates the hindbrain response to satiety signals.
The capacity to adjust energy intake in response to changing energy requirements is a defining feature of energy homeostasis. Despite the identification of leptin as a key mediator of this process, the mechanism whereby changes of body adiposity are coupled to adaptive, short-term adjustments of energy intake remains poorly understood. To investigate the physiological role of leptin in the cont...
متن کاملHindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin.
Leptin is thought to reduce food intake, in part, by increasing sensitivity to satiation signals, including CCK. Leptin action in both forebrain and hindbrain reduces food intake, and forebrain leptin action augments both the anorexic and neuronal activation responses to CCK. Here, we asked whether leptin signaling in hindbrain also enhances these responses to CCK. We found that food intake was...
متن کاملThe melanocortin system as a central integrator of direct and indirect controls of food intake.
THE NEURAL CONTROL OF FOOD INTAKE and body weight is a complex function in which cognitive and emotional variables, as well as long-term signals of metabolic status and fuel storage, are integrated with short-term signals related to individual meals. Several years ago, Smith (20) proposed a useful classification of the myriad signals that influence the amount of food eaten during individual mea...
متن کاملCALL FOR PAPERS Neural Integration of Peripheral Signals Implicated in the Control of Energy Homeostasis and Metabolism Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway
Babic T, Townsend RL, Patterson LM, Sutton GM, Zheng H, Berthoud HR. Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway. Am J Physiol Regul Integr Comp Physiol 296: R845–R854, 2009. First published January 28, 2009; doi:10.1152/ajpregu.90531.2008.—The satiating potency of CCK has been well characterized, including its media...
متن کاملEnergy Balance Effects of Central Melanocortin, Cocaine and Amphetamine Related Transcript and Leptin: Moving outside of the Hypothalamic Box
Due to increasing rates of obesity and its comorbidities, there is tremendous interest in the central nervous system (CNS) control of energy balance. This basic science interest is guided in part by the need to develop effective drugs for the overweight and the obese patient. Despite a large literature, our understanding of the circuits and neurochemical receptors that mediate energy balance is...
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